Dataset Information
Proteomic analysis of deletion mutants in Cronobacter sakazakii BAA-894
Ontology highlight
ABSTRACT:
ORGANISM(S): Cronobacter Sakazakii Atcc Baa-894
SUBMITTER: 
Xuemeng Ji
PROVIDER: PXD040672 | iProX | Tue Mar 07 00:00:00 GMT 2023
REPOSITORIES: iProX
Publications
Cronobacter sakazakii Pyridoxal Kinase PdxY Mediated by TreR and pESA3 Is Essential for Vitamin B<sub>6</sub> (PLP) Maintenance and Virulence.
Applied and environmental microbiology 20230717 8
Cronobacter sakazakii is an opportunistic pathogen capable of causing severe infections, particularly in neonates. Despite the bacterium's strong pathogenicity, the pathogenicity of C. sakazakii is not yet well understood. Using a comparative proteomic profiling approach, we successfully identified <i>pdxY</i>, encoding a pyridoxal kinase involved in the recycling of pyridoxal 5'-phosphate (PLP), as a gene essential for the successful pathogenesis of C. sakazakii. Knocking out the <i>pdxY</i> ge ...[more]
