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Proteomic analysis of Ganoderma sessile biotransformation of 15,16-dihydrotanshinone Ⅰ to obtain ganoderic acid

ABSTRACT: Biotransformation of 15,16-dihydrotanshinone Ⅰto shaker-cultured Ganoderma sessile mycelium to produce ganoderic acid, proteomic analysis of biotransformed mycelium and normal G. lsessile mycelium

ORGANISM(S): Ganoderma Sessile

SUBMITTER: Kun Feng

PROVIDER: PXD040674 | iProX | Tue Mar 07 00:00:00 GMT 2023

REPOSITORIES: iProX

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Biotransformation of triterpenoid ganoderic acids from exogenous diterpene dihydrotanshinone I in the cultures of Ganoderma sessile.

Wang Xinwei X Wu Haibo H Wong Ka Hong KH Wang Yixuan Y Chen Baixiong B Feng Kun K

Microbial cell factories 20230728 1

<h4>Background</h4>Triterpenoids have shown a wide range of biological activities including antitumor and antiviral effects. Typically, triterpenes are synthesized through the mevalonate pathway and are extracted from natural plants and fungi. In this work, triterpenoids, ganoderic acids (GAs) were discovered to be produced via biotransformation of a diterpene, 15,16-dihydrotanshinone I (DHT) in the liquid cultured Ganoderma sessile mycelium.<h4>Results</h4>Firstly, the biotransformation product ...[more]

PMID: 37507727

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