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The protein interaction of PALM2 in HEK 293T

ABSTRACT: We identify the protein interaction of PALM2 in HEK 293T. we find that PALM2 can promote the malignant behaviors of esophageal squamous cancer cell (ESCC). Focusing on the mechanism inside, we reveal that PALM2 promotes the migration of esophageal squamous cancer cells through activating it interactor, ezrin.

ORGANISM(S): Homo Sapiens

SUBMITTER: Liyan Xu

PROVIDER: PXD040700 | iProX | Wed Mar 08 00:00:00 GMT 2023

REPOSITORIES: iProX

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Prenylated PALM2 Promotes the Migration of Esophageal Squamous Cell Carcinoma Cells Through Activating Ezrin.

Deng Dan-Xia DX Li Cheng-Yu CY Zheng Zhen-Yuan ZY Wen Bing B Liao Lian-Di LD Zhang Xiao-Jun XJ Li En-Min EM Xu Li-Yan LY

Molecular & cellular proteomics : MCP 20230615 8

Proteins containing a CAAX motif at the C-terminus undergo prenylation for localization and activity and include a series of key regulatory proteins, such as RAS superfamily members, heterotrimeric G proteins, nuclear lamina protein, and several protein kinases and phosphatases. However, studies of prenylated proteins in esophageal cancer are limited. Here, through research on large-scale proteomic data of esophageal cancer in our laboratory, we found that paralemmin-2 (PALM2), a potential preny ...[more]

PMID: 37328063

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