Dataset Information
SET7 methylates the deubiquitinase OTUB1 at Lys 122
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Wuhan Xiao
PROVIDER: PXD040707 | iProX | Mon Jan 16 00:00:00 GMT 2023
REPOSITORIES: iProX
Publications
SET7 methylates the deubiquitinase OTUB1 at Lys <sup>122</sup> to impair its binding to E2 enzyme UBC13 and relieve its suppressive role on ferroptosis.
The Journal of biological chemistry 20230222 4
The deubiquitinating enzyme OTUB1 possesses canonical deubiquitinase (DUB) activity and noncanonical, catalytic-independent activity, which has been identified as an essential regulator of diverse physiological processes. Posttranslational modifications of OTUB1 affect both its DUB activity and its noncanonical activity of binding to the E2 ubiquitin-conjugation enzyme UBC13, but further investigation is needed to characterize the full inventory of modifications to OTUB1. Here, we demonstrate th ...[more]
