Proteomics

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Identification of PTENα associated proteins under stress condictions in B16 cells by mass spectrometry

ABSTRACT: PTENα is the first isoform of tumor suppressor PTEN. To investigate the molecular mechanism by which PTENα modulates cell response to inflammation, we performed pull-down assays with FLAG-tagged proteins coupled with mass spectrometry under condition of H2O2 treatment in B16 cells.

ORGANISM(S): Mus Musculus

SUBMITTER: Yuxin Yin  

PROVIDER: PXD040709 | iProX | Tue Jul 13 00:00:00 BST 2021

REPOSITORIES: iProX

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Publications

PTENα functions as an immune suppressor and promotes immune resistance in PTEN-mutant cancer.

Sun Yizhe Y   Lu Dan D   Yin Yue Y   Song Jia J   Liu Yang Y   Hao Wenyan W   Qi Fang F   Zhang Guangze G   Zhang Xin X   Liu Liang L   Lin Zhiqiang Z   Liang Hui H   Zhao Xuyang X   Jin Yan Y   Yin Yuxin Y  

Nature communications 20210826 1

PTEN is frequently mutated in human cancers and PTEN mutants promote tumor progression and metastasis. PTEN mutations have been implicated in immune regulation, however, the underlying mechanism is largely unknown. Here, we report that PTENα, the isoform of PTEN, remains active in cancer bearing stop-gained PTEN mutations. Through counteraction of CD8<sup>+</sup> T cell-mediated cytotoxicity, PTENα leads to T cell dysfunction and accelerates immune-resistant cancer progression. Clinical analysis  ...[more]

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