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Acute murine cytomegalovirus infection boosts cell-type specific response andlipid metabolism changes in infant mice liver

ABSTRACT: Human cytomegalovirus (HCMV) infection in infants cause severe diseasessuch as neonata hepatitis, However, the single-cell dimensiona description otthe immune cel alteration during the first virus exposure process in infantsremains poorly understood. The hepatocytes play an essential role in metabolichomeostasis and detoxification, The Concomitant Effects of CMV infection oriver lipid metabolism in infants are still unclear. Here, using single-cell RNAsequencing, we found MCMV can infect most cell types of infant mice liverchanging the number of immune cells, MCMV infection increases proliferatincsubset of Nos2+CD8 effectorcells and amonocytes，which may plalimportant roles in the early anti-viral process. Furthermore, MCMV infectiorsubvert the protein expression profile of lipid metabolism in hepatocytesOverall, our data provide insights as to how the immune system response toMCMY infection during the early stage of infection, and the impact of infectionon lipid metabolism in infant mice hepatocvtes.

ORGANISM(S): Mus Musculus

SUBMITTER: Weidong Jia

PROVIDER: PXD040842 | iProX | Mon Mar 13 00:00:00 GMT 2023

REPOSITORIES: iProX

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Acute murine cytomegalovirus infection boosts cell-type specific response and lipid metabolism changes in the liver of infant mice.

Gao Juanzi J Wang Anmin A Bu Xiangyi X Jia Weidong W

Frontiers in immunology 20230810

<h4>Introduction</h4>Human cytomegalovirus (HCMV) infection in infants can lead to severe diseases, including neonatal hepatitis. The single-cell dimensional changes in immune cells after the initial CMV infection remain elusive, as do the effects of CMV infection on hepatic lipid metabolism.<h4>Methods</h4>We employed single-cell RNA-sequencing to investigate the changes in liver cell types and immune responses in infant mice following murine CMV (MCMV) infection. Additionally, we examined alte ...[more]

PMID: 37638012

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Dataset Information

Acute murine cytomegalovirus infection boosts cell-type specific response andlipid metabolism changes in infant mice liver

Publications

Acute murine cytomegalovirus infection boosts cell-type specific response and lipid metabolism changes in the liver of infant mice.

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