Proteomics

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Identification of circEZH2_005-interacting proteins by mass spectrometry

ABSTRACT: liquid chromatography tandem mass spectrometry is used to identificate of the circEZH2_005-Interacting protein pulled down by circEZH2_005 junction probe with protein extracts from Intestinal crypt cells.

ORGANISM(S): Mus Musculus

SUBMITTER: Kexuan Liu  

PROVIDER: PXD040925 | iProX | Fri Mar 17 00:00:00 GMT 2023

REPOSITORIES: iProX

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Publications

Exosomal circEZH2_005, an intestinal injury biomarker, alleviates intestinal ischemia/reperfusion injury by mediating Gprc5a signaling.

Zhang Wenjuan W   Zhou Bowei B   Yang Xiao X   Zhao Jin J   Hu Jingjuan J   Ding Yuqi Y   Zhan Shuteng S   Yang Yifeng Y   Chen Jun J   Zhang Fu F   Zhao Bingcheng B   Deng Fan F   Lin Zebin Z   Sun Qishun Q   Zhang Fangling F   Yao Zhiwen Z   Liu Weifeng W   Li Cai C   Liu Ke-Xuan KX  

Nature communications 20230906 1

Intestinal ischemia/reperfusion (I/R) injury is a severe clinical condition without optimal diagnostic markers nor clear molecular etiological insights. Plasma exosomal circular RNAs (circRNAs) are valuable biomarkers and therapeutic targets for various diseases, but their role in intestinal I/R injury remains unknown. Here we screen the expression profile of circRNAs in intestinal tissue exosomes collected from intestinal I/R mice and identify circEZH2_005 as a significantly downregulated exoso  ...[more]

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