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Gel-based LC-MSMS, the interactome of XAF1 in 293T cells

ABSTRACT: We utilized mass spectrometry to analyze the interacting proteins of XAF1 in 293T cells.

ORGANISM(S): Homo Sapiens

SUBMITTER: JingJing Li

PROVIDER: PXD041021 | iProX | Wed Mar 22 00:00:00 GMT 2023

REPOSITORIES: iProX

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XAF1 promotes colorectal cancer metastasis via VCP-RNF114-JUP axis.

Xia Ji J Ma Ning N Shi Qian Q Liu Qin-Cheng QC Zhang Wei W Cao Hui-Jun HJ Wang Yi-Kang YK Zheng Qian-Wen QW Ni Qian-Zhi QZ Xu Sheng S Zhu Bing B Qiu Xiao-Song XS Ding Kai K Huang Jing-Yi JY Liang Xin X Chen Yu Y Xiang Yan-Jun YJ Zhang Xi-Ran XR Qiu Lin L Chen Wei W Xie Dong D Wang Xiang X Long Lingyun L Li Jing-Jing JJ

The Journal of cell biology 20231214 2

Metastasis is the main cause of colorectal cancer (CRC)-related death, and the 5-year relative survival rate for CRC patients with distant metastasis is only 14%. X-linked inhibitor of apoptosis (XIAP)-associated factor 1 (XAF1) is a zinc-rich protein belonging to the interferon (IFN)-induced gene family. Here, we report a metastasis-promoting role of XAF1 in CRC by acting as a novel adaptor of valosin-containing protein (VCP). XAF1 facilitates VCP-mediated deubiquitination of the E3 ligase RING ...[more]

PMID: 38095639

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