Proteomics

Dataset Information

0

TBK1 methylation site identification

ABSTRACT: Identification of TBK1 methylated residues by recombinant SETD4 protein

ORGANISM(S): Homo Sapiens

SUBMITTER: Mingxiong Guo  

PROVIDER: PXD041084 | iProX | Fri Mar 24 00:00:00 GMT 2023

REPOSITORIES: iProX

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Publications

TBK1-stabilized ZNF268a recruits SETD4 to methylate TBK1 for efficient interferon signaling.

Liu Yi Y   Yin Wei W   Zeng Xianhuang X   Fan Jinhao J   Liu Chaozhi C   Gao Mingyu M   Huang Zan Z   Sun Guihong G   Guo Mingxiong M  

The Journal of biological chemistry 20231104 12

Sufficient activation of interferon signaling is critical for the host to fight against invading viruses, in which post-translational modifications have been demonstrated to play a pivotal role. Here, we demonstrate that the human KRAB-zinc finger protein ZNF268a is essential for virus-induced interferon signaling. We find that cytoplasmic ZNF268a is constantly degraded by lysosome and thus remains low expressed in resting cell cytoplasm. Upon viral infection, TBK1 interacts with cytosolic ZNF26  ...[more]