Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: Jiahuai Han
PROVIDER: PXD041115 | iProX | Sat Mar 25 00:00:00 GMT 2023
REPOSITORIES: iProX
Wu Xiurong X Yang Zhang-Hua ZH Wu Jianfeng J Han Jiahuai J
Immunity 20230321 5
NOD-like receptors (NLRs) are pattern recognition receptors for diverse innate immune responses. Self-oligomerization after engagement with a ligand is a generally accepted model for the activation of each NLR. We report here that a catalyzer was required for NLR self-oligomerization. PELO, a well-known surveillance factor in translational quality control and/or ribosome rescue, interacted with all cytosolic NLRs and activated their ATPase activity. In the case of flagellin-initiated NLRC4 infla ...[more]