Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: Ming He
PROVIDER: PXD041145 | iProX | Mon Mar 27 00:00:00 BST 2023
REPOSITORIES: iProX
Lin Longshuai L Guo Zengya Z He Enjun E Long Xidai X Wang Difei D Zhang Yingting Y Guo Weihong W Wei Qian Q He Wei W Wu Wanying W Li Jingchi J Wo Lulu L Hong Dengli D Zheng Junke J He Ming M Zhao Qinghua Q
Nature metabolism 20230515 5
The interplay between liver and bone metabolism remains largely uncharacterized. Here, we uncover a mechanism of liver-bone crosstalk regulated by hepatocyte SIRT2. We demonstrate that hepatocyte SIRT2 expression is increased in aged mice and elderly humans. Liver-specific SIRT2 deficiency inhibits osteoclastogenesis and alleviates bone loss in mouse models of osteoporosis. We identify leucine-rich α-2-glycoprotein 1 (LRG1) as a functional cargo in hepatocyte-derived small extracellular vesicles ...[more]