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O-GlcNAcylation elevates topoisomerase IIα catalytic activity: a role in the chemotherapy resistance of breast cancer

ABSTRACT: DNA topoisomerase IIα (TOP2A) plays a vital role in replication and cell division by catalytically altering DNA topology. It is a prominent target for anticancer drugs. However, it is currently unknown whether TOP2A is O-GlcNAc-modified, and the mechanism by which interplay between TOP2A and O-GlcNAcylation affects breast cancer chemotherapeutic drug resistance remains unclear.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yubo Liu

PROVIDER: PXD041284 | iProX | Fri Mar 31 00:00:00 BST 2023

REPOSITORIES: iProX

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O-GlcNAcylation promotes topoisomerase IIα catalytic activity in breast cancer chemoresistance.

Liu Yangzhi Y Yu Kairan K Zhang Keren K Niu Mingshan M Chen Qiushi Q Liu Yajie Y Wang Lingyan L Zhang Nana N Li Wenli W Zhong Xiaomin X Li Guohui G Wu Sijin S Zhang Jianing J Liu Yubo Y

EMBO reports 20230530 7

DNA topoisomerase IIα (TOP2A) plays a vital role in replication and cell division by catalytically altering DNA topology. It is a prominent target for anticancer drugs, but clinical efficacy is often compromised due to chemoresistance. In this study, we investigate the role of TOP2A O-GlcNAcylation in breast cancer cells and patient tumor tissues. Our results demonstrate that elevated TOP2A, especially its O-GlcNAcylation, promotes breast cancer malignant progression and resistance to adriamycin ...[more]

PMID: 37249035

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