Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Shengcai Lin
PROVIDER: PXD041361 | iProX | Tue Apr 04 00:00:00 BST 2023
REPOSITORIES: iProX
Publications
Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate.
Wu Yu-Qing YQ Zhang Chen-Song CS Xiong Jinye J Cai Dong-Qi DQ Wang Chen-Zhe CZ Wang Yu Y Liu Yan-Hui YH Wang Yu Y Li Yiming Y Wu Jian J Wu Jianfeng J Lan Bin B Wang Xuefeng X Chen Siwei S Cao Xianglei X Wei Xiaoyan X Hu Hui-Hui HH Guo Huiling H Yu Yaxin Y Ghafoor Abdul A Xie Changchuan C Wu Yaying Y Xu Zheni Z Zhang Cixiong C Zhu Mingxia M Huang Xi X Sun Xiufeng X Lin Shu-Yong SY Piao Hai-Long HL Zhou Jianyin J Lin Sheng-Cai SC
Cell research 20230919 11
Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals, controlling metabolic states beyond energy metabolism. However, whether glycolytic metabolites also play a role in controlling cell fate remains unexplored. Here, we find that low levels of glycolytic metabolite 3-phosphoglycerate (3-PGA) can switch phosphoglycerate dehydrogenase (PHGDH) from cataplerosis serine synthesis to pro-apoptotic activation of p53. PHGDH is a p53-binding protein, and when unoccup ...[more]
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