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Proteins that interacted with THOC3 in lung squamous cell carcinoma

ABSTRACT: Lung squamous cell carcinoma cells were transfected by THOC3 overexpressed plasmids with FLag-tag. Then anti-Flag antibodies were utilized and proteins bound to THOC3 were analyzed by mass spectrometry.

ORGANISM(S): Homo Sapiens

SUBMITTER: Kaihua Lu

PROVIDER: PXD041447 | iProX | Mon Apr 10 00:00:00 BST 2023

REPOSITORIES: iProX

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THOC3 interacts with YBX1 to promote lung squamous cell carcinoma progression through PFKFB4 mRNA modification.

Yu Tao T Zhang Qi Q Yu Shao-Kun SK Nie Feng-Qi FQ Zhang Mei-Ling ML Wang Qian Q Lu Kai-Hua KH

Cell death & disease 20230727 7

The THO complex (THOC) is ubiquitously involved in RNA modification and various THOC proteins have been reported to regulate tumor development. However, the role of THOC3 in lung cancer remains unknown. In this study, we identified that THOC3 was highly expressed in lung squamous cell carcinoma (LUSC) and negatively associated with prognosis. THOC3 knockdown inhibited LUSC cell growth, migration, and glycolysis. THOC3 expression was regulated by TRiC proteins, such as CCT8 and CCT6A, which suppo ...[more]

PMID: 37500615

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