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Proteomics Characteristics Reveal the Risk of T1 Colorectal Cancer Metastasis to Lymph Nodes

ABSTRACT: The presence of lymph node metastasis (LNM) affects treatment strategy decisions in T1NxM0 colorectal cancer (CRC), but the currently used clinicopathological-based risk stratification cannot be used to accurately predict LNM. In this study, we established a model for predicting LNM and explored the mechanism of metastasis in T1 CRC.

ORGANISM(S): Homo Sapiens

SUBMITTER: Chen Ding

PROVIDER: PXD041476 | iProX | Wed Apr 12 00:00:00 BST 2023

REPOSITORIES: iProX

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Proteomic characteristics reveal the signatures and the risks of T1 colorectal cancer metastasis to lymph nodes.

Zhuang Aojia A Zhuang Aobo A Chen Yijiao Y Qin Zhaoyu Z Zhu Dexiang D Ren Li L Wei Ye Y Zhou Pengyang P Yue Xuetong X He Fuchu F Xu Jianmin J Ding Chen C

eLife 20230509

The presence of lymph node metastasis (LNM) affects treatment strategy decisions in T1NxM0 colorectal cancer (CRC), but the currently used clinicopathological-based risk stratification cannot predict LNM accurately. In this study, we detected proteins in formalin-fixed paraffin-embedded (FFPE) tumor samples from 143 LNM-negative and 78 LNM-positive patients with T1 CRC and revealed changes in molecular and biological pathways by label-free liquid chromatography tandem mass spectrometry (LC-MS/MS ...[more]

PMID: 37158593

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