Proteomics

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Anti-biofilm effect of salivary histatin 5 on Porphyromonas gingivalis


ABSTRACT: investigate the effects of salivary histatin 5 (Hst5) on Porphyromonas gingivalis (P. gingivalis) biofilms in vitro and in vivo and the possible mechanisms.

ORGANISM(S): Porphyromonas Gingivalis W83

SUBMITTER: Rui Li  

PROVIDER: PXD041477 | iProX | Wed Apr 12 00:00:00 GMT+01:00 2023

REPOSITORIES: iProX

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Anti-biofilm effect of salivary histatin 5 on Porphyromonas gingivalis.

Li Rui R   Hou Mengjie M   Yu Liying L   Luo Wen W   Kong Jie J   Yu Renmei R   Liu Ruihan R   Li Qian Q   Tan Lisi L   Pan Chunling C   Wang Hongyan H  

Applied microbiology and biotechnology 20230703 16


This study aimed to investigate the effects of salivary histatin 5 (Hst5) on Porphyromonas gingivalis (P. gingivalis) biofilms in vitro and in vivo and the possible mechanisms. In in vitro experiments, P. gingivalis biomass was determined by crystal violet staining. Polymerase chain reaction, scanning electron microscopy, and confocal laser scanning microscopy were used to determine the Hst5 concentration. A search for potential targets was performed using transcriptomic and proteomic analyses.  ...[more]

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