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Acetylome of acetyltransferase SCO0988 overexpression in S. lividans TK24

ABSTRACT: When SCO0988 was overexpressed in Streptomyces lividans TK24, it reveals the mechanism of acetyltransferase SCO0988 on regulating secondary metabolism by comparing acetylome of overexpressed strains and control strains

ORGANISM(S): Streptomyces Lividans Tk24

SUBMITTER: Delin Xu

PROVIDER: PXD041540 | iProX | Fri Apr 14 00:00:00 BST 2023

REPOSITORIES: iProX

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The acetyltransferase SCO0988 controls positively specialized metabolism and morphological differentiation in the model strains <i>Streptomyces coelicolor</i> and <i>Streptomyces lividans</i>.

Bi Yunwen Y An Hao H Chi Zhewei Z Xu Zhongheng Z Deng Yuan Y Ren Yuxian Y Wang Rui R Lu Xinyi X Guo Jia J Hu Ren R Virolle Marie-Joelle MJ Xu Delin D

Frontiers in microbiology 20240724

Streptomycetes are well-known antibiotic producers possessing in their genomes numerous silent biosynthetic pathways that might direct the biosynthesis of novel bio-active specialized metabolites. It is thus of great interest to find ways to enhance the expression of these pathways to discover most needed novel antibiotics. In this study, we demonstrated that the over-expression of acetyltransferase SCO0988 up-regulated the production of specialized metabolites and accelerated sporulation of the ...[more]

PMID: 39113837

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