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Proteomics of Staphylococcus aureus

ABSTRACT: Tannic acid (TA) and punicalagin(P), which both are polyphenols, have attracted much attention in recent years due to its extensive physiological activities, which include antioxidant, antitumoral, antimicrobial and anti-inflammatory actions. Previous work revealed that TA has an inhibitory effect on a variety of bacteria, including S. aureus, Salmonella, and Lactobacillus. Previous researches suggested that TA inhibited bacterial growth by chelating ions from the culture medium, and by inhibiting fatty acid synthesis through suppression of the activity of β-ketoacyl-ACP reductase, or by interfering with cell wall integrity. However, the mechanisms underlying the inhibitory effect of TA and P on S.aureus have not been assessed comprehensively. Therefore, the present study combined transcriptome and proteome data to analyze the molecular mechanisms of TA and P in S. aureus.

ORGANISM(S): Staphylococcus Aureus

SUBMITTER: Jing Wang

PROVIDER: PXD041839 | iProX | Wed Apr 26 00:00:00 BST 2023

REPOSITORIES: iProX

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Combined proteomic and transcriptomic analysis of the antimicrobial mechanism of tannic acid against Staphylococcus aureus.

Wang Jing J Sheng Zhicun Z Liu Yunying Y Chen Xiaolan X Wang Shuaibing S Yang Haifeng H

Frontiers in pharmacology 20230816

Staphylococcus aureus is a zoonotic opportunistic pathogen that represents a significant threat to public health. Previous studies have shown that tannic acid (TA) has an inhibitory effect on a variety of bacteria. In this study, the proteome and transcriptome of S. aureus were analyzed to comprehensively assess changes in genes and proteins induced by TA. Initial observations of morphological changes revealed that TA damaged the integrity of the cell membrane. Next, proteomic and ...[more]

PMID: 37654613

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