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The Study of Chinese Medicine Intervention on Apoptosis of Cochlear hair cells in C57BL/6J Aged Cochlea

ABSTRACT: Through the intervention of traditional Chinese medicine prescription on cochlear hair cell apoptosis of c57 mice to 7-month-old mice, the proteomic analysis of cochlear hair cell apoptosis of 7-month-old mice and 2-month-old mice in the non traditional Chinese medicine group was compared to try to find the target or related pathway of Chinese medicine affecting cochlear senile apoptosis.

ORGANISM(S): Mus Musculus

SUBMITTER: Weijun Xuan

PROVIDER: PXD041998 | iProX | Thu May 04 00:00:00 BST 2023

REPOSITORIES: iProX

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Use of the traditional Chinese medicine "compound healthy ear agent" to protect against age-related hearing loss in mice: A proteomics study.

Xuan Weijun W Huang Liyi L Xuan Yi Y Chen Sizhong S Tang Junbo J Wei Yulong Y Pan Xu X Hamblin Michael R MR

Heliyon 20240225 5

<h4>Background</h4>Previous studies have shown that the traditional Chinese medicine (TCM) called "compound healthy ear agent" (CHEA) had anti-apoptosis effects in cochlear hair cells and spiral ganglion neurons, and could protect mice hearing against presbycusis or age-related hearing loss (AHL), as well as aminoglycoside antibiotic-induced ototoxicity. Because its mechanisms of action are still unclear, we investigated the mechanism of action of CHEA against AHL in mice using proteomics techni ...[more]

PMID: 38434421

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