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Metaproteomics characterizes human gingival crevicular fluid microbiome function in periodontitis

ABSTRACT: The human gingival crevicular fluid proteome and metaproteome of periodontitis are investigated, to shed light on the factors that mediate the host-microbiota interactions in the pathogenesis of periodontitis.

ORGANISM(S): Homo Sapiens

SUBMITTER: Wei Sun

PROVIDER: PXD042037 | iProX | Sat May 06 00:00:00 GMT+01:00 2023

REPOSITORIES: iProX

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Metaproteomics Characterizes the Human Gingival Crevicular Fluid Microbiome Function in Periodontitis.

Xiao Xiaolian X Xiao Xiaoping X Liu Yaoran Y Sun Haidan H Liu Xiaoyan X Guo Zhengguang Z Li Qian Q Sun Wei W

Journal of proteome research 20230616 7

Periodontitis is the leading cause of tooth loss in adults worldwide. The human proteome and metaproteome characterization of periodontitis is not clearly understood. Gingival crevicular fluid samples were collected from eight periodontitis and eight healthy subjects. Both the human and microbial proteins were characterized by liquid chromatography coupled with high-resolution mass spectrometry. A total of 570 human proteins were found differentially expressed, which were primarily associated wi ...[more]

PMID: 37327455

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