Dataset Information
Indentification of the interaction proteins of DPPA5A in mouse embryonic stem cells
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Ping Zheng
PROVIDER: PXD042052 | iProX | Mon May 08 00:00:00 BST 2023
REPOSITORIES: iProX
Publications
DPPA5A suppresses the mutagenic TLS and MMEJ pathways by modulating the cryptic splicing of <i>Rev1</i> and <i>Polq</i> in mouse embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America 20230717 30
Genetic alterations are often acquired during prolonged propagation of pluripotent stem cells (PSCs). This ruins the stem cell quality and hampers their full applications. Understanding how PSCs maintain genomic integrity would provide the clues to overcome the hurdle. It has been known that embryonic stem cells (ESCs) utilize high-fidelity pathways to ensure genomic stability, but the underlying mechanisms remain largely elusive. Here, we show that many DNA damage response and repair genes disp ...[more]
