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Improving impact of heparan sulfate on the endothelial glycocalyx abnormalities in atherosclerosis as revealed by glycan-protein interactome

ABSTRACT: Based on glycan-protein interactome, these data expanded the list of known HSBPs and identified them as key proteins in the development of atherosclerosis.

ORGANISM(S): Homo Sapiens

SUBMITTER: Lianli Chi

PROVIDER: PXD042279 | iProX | Tue Oct 10 00:00:00 BST 2023

REPOSITORIES: iProX

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Improving impact of heparan sulfate on the endothelial glycocalyx abnormalities in atherosclerosis as revealed by glycan-protein interactome.

Chen Qingqing Q Xu Xiaohui X Xie Shaoshuai S Sheng Anran A Han Naihan N Tian Zhenyu Z Wang Xiaowei X Li Fuchuan F Linhardt Robert J RJ Zhang Fuming F Jin Lan L Zhang Qunye Q Chi Lianli L

Carbohydrate polymers 20240118

Endothelial dysfunction induced by oxidative stress is an early predictor of atherosclerosis, which can cause various cardiovascular diseases. The glycocalyx layer on the endothelial cell surface acts as a barrier to maintain endothelial biological function, and it can be impaired by oxidative stress. However, the mechanism of glycocalyx damage during the development of atherosclerosis remains largely unclear. Herein, we established a novel strategy to address these issues from the glycomic pers ...[more]

PMID: 38368111

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