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Identification of new binding partners for the vaccinia virus protein C4

ABSTRACT: Two sets of TMT-MS to identify binding partners of vaccinia virus C4

ORGANISM(S): Homo Sapiens

SUBMITTER: Geoffrey Smith

PROVIDER: PXD042378 | iProX | Tue Feb 20 00:00:00 GMT 2024

REPOSITORIES: iProX

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Filamin B restricts vaccinia virus spread and is targeted by vaccinia virus protein C4.

Georgana Iliana I Scutts Simon R SR Gao Chen C Lu Yongxu Y Torres Alice A AA Ren Hongwei H Emmott Edward E Men Jinghao J Oei Keefe K Smith Geoffrey L GL

Journal of virology 20240227 3

Vaccinia virus (VACV) is a large DNA virus that encodes scores of proteins that modulate the host immune response. VACV protein C4 is one such immunomodulator known to inhibit the activation of both the NF-κB signaling cascade and the DNA-PK-mediated DNA sensing pathway. Here, we show that the N-terminal region of C4, which neither inhibits NF-κB nor mediates interaction with DNA-PK, still contributes to virus virulence. Furthermore, this domain interacts directly and with high affinity to the C ...[more]

PMID: 38412044

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