Dataset Information
Identification of new binding partners for the vaccinia virus protein C4
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Geoffrey Smith
PROVIDER: PXD042378 | iProX | Tue Feb 20 00:00:00 GMT 2024
REPOSITORIES: iProX
Publications
Filamin B restricts vaccinia virus spread and is targeted by vaccinia virus protein C4.
Journal of virology 20240227 3
Vaccinia virus (VACV) is a large DNA virus that encodes scores of proteins that modulate the host immune response. VACV protein C4 is one such immunomodulator known to inhibit the activation of both the NF-κB signaling cascade and the DNA-PK-mediated DNA sensing pathway. Here, we show that the N-terminal region of C4, which neither inhibits NF-κB nor mediates interaction with DNA-PK, still contributes to virus virulence. Furthermore, this domain interacts directly and with high affinity to the C ...[more]
