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Identified small open reading frame encoded peptides in plasma with nanoparticle protein coronas

ABSTRACT: We identified small open reading frames encoded peptided in human serum with nanoparticle protein coronas method using mass spectrometry. Four nanoparticle material treatments (TiO2, Fe3O4@SiO2, Fe3O4@SiO2@TiO2, NPs-mix), ACN and untreated control were performed with triplicates. The comparision of 96 well plate and centrifuge tube was carried out with 6 replicates and 4 replicates respectively.

ORGANISM(S): Homo Sapiens

SUBMITTER: Cuihong Wan

PROVIDER: PXD042459 | iProX | Wed May 24 00:00:00 GMT+01:00 2023

REPOSITORIES: iProX

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Identified Small Open Reading Frame-Encoded Peptides in Human Serum with Nanoparticle Protein Coronas.

Peng Mingbo M Zhou Yutian Y Wang Yi Y Yi Zi Z Li Shenglan S Wan Cuihong C

Journal of proteome research 20231125 1

The low-molecular-weight proteins (LMWP) in serum and plasma are related to various human diseases and can be valuable biomarkers. A small open reading frame-encoded peptide (SEP) is one kind of LMWP, which has been found to function in many bioprocesses and has also been found in human blood, making it a potential biomarker. The detection of LMWP by a mass spectrometry (MS)-based proteomic assay is often inhibited by the wide dynamic range of serum/plasma protein abundance. Nanoparticle protein ...[more]

PMID: 38006349

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