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DIA-PRM Proteomic Study of Tissue Samples Reveals Modulated Pathways and Biomarkers Related to Pelvic Organ Prolapse

ABSTRACT: To discover potential biomarker(s) for POP diagnosis and explore the molecular mechanism underlying the disease, we here applied an untargeted data-independent acquisition (DIA)-based proteomics approach on vaginal wall tissue samples from patients with POP (n = 19) and controls (n = 8).

ORGANISM(S): Homo Sapiens

SUBMITTER: Jun Rao

PROVIDER: PXD042491 | iProX | Thu May 25 00:00:00 BST 2023

REPOSITORIES: iProX

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4D DIA-PRM proteomic study identifying modulated pathways and biomarkers associated with pelvic organ prolapse.

Deng Wei W Zhong Zhifeng Z Tong Yuehong Y Liu Jun J Wang Xiaofen X Xu Lili L Li Yufeng Y Chen Xiaodan X Wei Qingfeng Q Rao Jun J

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20231029

Pelvic organ prolapse (POP) is a highly disabling condition that negatively affects the quality of life of millions of women worldwide. However, the underlying mechanisms associated with the development and progression of the disease remain poorly understood. Here, an untargeted four-dimensional data-independent acquisition (4D DIA)-based proteomics approach was applied to vaginal wall tissue samples from POP (n = 19) and control (n = 8) patients to identify potential diagnostic biomarker(s) for ...[more]

PMID: 37922782

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