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Establishment and clinical application evaluations of a deep mining strategy of plasma proteomics based on nanomaterial protein coronas

ABSTRACT: In this study, a deep mining strategy of plasma proteomics was established by combing the protein corona formed by deep mining beads (DMB beads, hereafter referred to as magnetic covalent organic frameworks Fe3O4@TpPa-1), DIA-MS detection and the DIA-NN library searching method.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yan Zhao

PROVIDER: PXD042554 | iProX | Wed May 31 00:00:00 BST 2023

REPOSITORIES: iProX

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Establishment and clinical application evaluations of a deep mining strategy of plasma proteomics based on nanomaterial protein coronas.

Wang Jianan J Xie Wei W Sun Longqin L Li Jingli J Wu Songfeng S Li Ruibing R Zhao Yan Y

Analytica chimica acta 20230704

Research on plasma proteomics has received extensive attention, because human plasma is an important sample for disease biomarker research due to its easy clinical accessibility and richness in biological information. Plasma samples contain a large number of leaked proteins from different tissues in the body, immune proteins and communication signal proteins. However, MS signal suppression from high-abundance proteins results in a large number of proteins that are present in low abundance in pla ...[more]

PMID: 37524462

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