A new long-acting tissue kallikrein ameliorates ischemic stroke injury by inhibiting HMGB1-related neuroinflammation and apoptosis-ip
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ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Xiang Cao
PROVIDER: PXD042778 | iProX | Wed Jun 07 00:00:00 BST 2023
REPOSITORIES: iProX
Publications
QHRD106 ameliorates ischemic stroke injury as a long-acting tissue kallikrein preparation.
Xu Si-Yi SY Jia Jun-Qiu JQ Sun Min M Bao Xin-Yu XY Xia Sheng-Nan SN Shu Shu S Liu Pin-Yi PY Ji Sen-Lin SL Ye Lei L Cao Xiang X Xu Yun Y
iScience 20230703 7
Ischemic stroke is the second leading cause of death worldwide, and there are limited effective treatment strategies. QHRD106, a polyethyleneglycol (PEG)-modified long-acting tissue kallikrein preparation, has not been reported previously. In this study, we aimed to investigate the therapeutic effect of QHRD106 in ischemic stroke and its possible mechanism. We found that QHRD106 treatment alleviated brain injury after stroke via bradykinin (BK) receptor B2 (B2R) instead of BK receptor B1 (B1R). ...[more]
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