Proteomic profiling and tumor microenvironment characterization reveal molecular and immunological hallmarks of left-sided and right-sided colon cancer tumorigenesis
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Yi Zhou
PROVIDER: PXD042962 | iProX | Tue Jun 13 00:00:00 BST 2023
REPOSITORIES: iProX
Publications
Proteomic Profiling and Tumor Microenvironment Characterization Reveal Molecular and Immunological Hallmarks of Left-Sided and Right-Sided Colon Cancer Tumorigenesis.
Hong Zhu Z Wang Tao T Wang Wei W Jing Haoren H Tang Hongzhen H Xu Mingyue M Pan Chaohu C Mu Xiaojing X Zhang Di D Gao Guochao G Gao Zihe Z Luo Haitao H Zhou Yi Y
Journal of proteome research 20230817 9
Left-sided and right-sided colon cancer (LSCC and RSCC) display different biological and clinical characteristics. However, the differences in their tumorigenesis and tumor microenvironment remain unclear. In this study, we profiled the proteomic landscapes of LSCC and RSCC with data-independent acquisition mass spectrometry (DIA-MS) using fresh tumor and adjacent normal tissues from 24 patients. A total of 7403 proteingroups were primarily identified with DIA-MS. After quality control, 7212 pro ...[more]
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