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Comparative proteomic analysis identifies differentially expressed proteins associated with meiotic arrest in cattle-yak hybrids

ABSTRACT: Comparative proteomic analysis identified a total of 452 differentially abundant proteins (DAPs) in the fluorescence-activated cell sorting (FACS) isolated spermatocytes from 12-month-old yak and cattleyak. 291 proteins were only identified in yak spermatocytes. Gene Ontology analysis revealed that the downregulated DAPs were mostly enriched in the cellular response to DNA damage stimulus and double-strand break (DSB) repair via break-induced replication, while the proteins specific for yak were related to cell division and cycle, spermatogenesis, and negative regulation of the extrinsic apoptotic signaling pathway.

ORGANISM(S): Bos Mutus

SUBMITTER: Qien Yang

PROVIDER: PXD043039 | iProX | Tue Mar 21 00:00:00 GMT 2023

REPOSITORIES: iProX

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