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Proteomic signature to predict ACT in CRC

ABSTRACT: High-throughput proteomics profiling-derived signature associated with chemotherapy response and survival for stage II/III colorectal cancer

ORGANISM(S): Homo Sapiens

SUBMITTER: Ping Lan

PROVIDER: PXD043116 | iProX | Mon Jun 19 00:00:00 BST 2023

REPOSITORIES: iProX

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High-throughput proteomics profiling-derived signature associated with chemotherapy response and survival for stage II/III colorectal cancer.

Ye Shu-Biao SB Cheng Yi-Kan YK Li Pei-Si PS Zhang Lin L Zhang Lian-Hai LH Huang Yan Y Chen Ping P Wang Yi Y Wang Chao C Peng Jian-Hong JH Shi Li-Shuo LS Ling Li L Wu Xiao-Jian XJ Qin Jun J Yang Zi-Huan ZH Lan Ping P

NPJ precision oncology 20230531 1

Adjuvant chemotherapy (ACT) is usually used to reduce the risk of disease relapse and improve survival for stage II/III colorectal cancer (CRC). However, only a subset of patients could benefit from ACT. Thus, there is an urgent need to identify improved biomarkers to predict survival and stratify patients to refine the selection of ACT. We used high-throughput proteomics to analyze tumor and adjacent normal tissues of stage II/III CRC patients with /without relapse to identify potential markers ...[more]

PMID: 37258779

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