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4D-diaXLMS: Proteome-wide Four-Dimensional Data-Independent Acquisition Workflow for Cross-linking Mass Spectrometry

ABSTRACT: Cross-linking Mass Spectrometry (XL-MS) is a powerful tool for examining protein structures and interactions. Nevertheless, anal-ysis of low-abundance cross-linked peptides is often limited in data-dependent acquisition (DDA) mode due to its semistochastic nature. To address this issue, we introduced a workflow called 4D-diaXLMS, representing the first-ever application of four-dimensional data-independent acquisition for proteome-wide cross-linking analysis.

ORGANISM(S): Homo Sapiens Saccharomyces Cerevisiae

SUBMITTER: Suming Chen

PROVIDER: PXD043282 | iProX | Mon Jun 26 00:00:00 BST 2023

REPOSITORIES: iProX

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