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Proteomic analysis of the four rat models of depression

ABSTRACT: Major depressive disorder (MDD) is a highly heterogeneous psychiatric disorder. The pathogenesis of MDD remained unclear, and it may be associated with exposure to different stressors. Most previous studies have focused on molecular changes in a single stress-induced depression model, which limited the identification of the pathogenesis of MDD. The depressive-like behaviors were induced by four well-validated stress models in rats, including chronic unpredictable mild stress, learned helplessness stress, chronic restraint stress and social defeat stress. We applied proteomic to investigate molecular changes in the hippocampus of those four models and revealed 529 proteins.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Peng Xie

PROVIDER: PXD043285 | iProX | Mon May 22 00:00:00 BST 2023

REPOSITORIES: iProX

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AKT and MAPK signaling pathways in hippocampus reveals the pathogenesis of depression in four stress-induced models.

Li Xuemei X Teng Teng T Yan Wei W Fan Li L Liu Xueer X Clarke Gerard G Zhu Dan D Jiang Yuanliang Y Xiang Yajie Y Yu Ying Y Zhang Yuqing Y Yin Bangmin B Lu Lin L Zhou Xinyu X Xie Peng P

Translational psychiatry 20230612 1

Major depressive disorder (MDD) is a highly heterogeneous psychiatric disorder. The pathogenesis of MDD remained unclear, and it may be associated with exposure to different stressors. Most previous studies have focused on molecular changes in a single stress-induced depression model, which limited the identification of the pathogenesis of MDD. The depressive-like behaviors were induced by four well-validated stress models in rats, including chronic unpredictable mild stress, learned helplessnes ...[more]

PMID: 37308476

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