Proteomic Dynamics of Breast Cancer Cell Lines Identifies Potential Therapeutic Protein Targets
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ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: 
Yi Zhu
PROVIDER: PXD043471 | iProX | Mon Jul 03 00:00:00 BST 2023
REPOSITORIES: iProX
Publications
Proteomic Dynamics of Breast Cancer Cell Lines Identifies Potential Therapeutic Protein Targets.
Sun Rui R Ge Weigang W Zhu Yi Y Sayad Azin A Luna Augustin A Lyu Mengge M Liang Shuang S Tobalina Luis L Rajapakse Vinodh N VN Yu Chenhuan C Zhang Huanhuan H Fang Jie J Wu Fang F Xie Hui H Saez-Rodriguez Julio J Ying Huazhong H Reinhold William C WC Sander Chris C Pommier Yves Y Neel Benjamin G BG Aebersold Ruedi R Guo Tiannan T
Molecular & cellular proteomics : MCP 20230619 8
Treatment and relevant targets for breast cancer (BC) remain limited, especially for triple-negative BC (TNBC). We identified 6091 proteins of 76 human BC cell lines using data-independent acquisition (DIA). Integrating our proteomic findings with prior multi-omics datasets, we found that including proteomics data improved drug sensitivity predictions and provided insights into the mechanisms of action. We subsequently profiled the proteomic changes in nine cell lines (five TNBC and four non-TNB ...[more]
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