Proteomics

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Discovery of Cisplatin-binding Proteins by Competitive Cysteinome Profiling


ABSTRACT: Cisplatin is a widely-used cancer metallodrug which induces cytotoxicity by targeting DNA and chelating cysteines in proteins. Here we applied a competitive activity-based protein profiling strategy to identify cisplatin-binding cysteines in cancer proteomes. A novel cisplatin target, MetAP1, was found and functionally validated to contribute to cisplatin’s cytotoxicity.

ORGANISM(S): Homo Sapiens

SUBMITTER: Chu Wang  

PROVIDER: PXD043629 | iProX | Sat Jul 08 00:00:00 BST 2023

REPOSITORIES: iProX

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