Discovery of Cisplatin-binding Proteins by Competitive Cysteinome Profiling
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ABSTRACT: Cisplatin is a widely-used cancer metallodrug which induces cytotoxicity by targeting DNA and chelating cysteines in proteins. Here we applied a competitive activity-based protein profiling strategy to identify cisplatin-binding cysteines in cancer proteomes. A novel cisplatin target, MetAP1, was found and functionally validated to contribute to cisplatin’s cytotoxicity.
ORGANISM(S): Homo Sapiens
SUBMITTER: Chu Wang
PROVIDER: PXD043629 | iProX | Sat Jul 08 00:00:00 BST 2023
REPOSITORIES: iProX
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