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Proteomic profiling of chirality-biased bone regeneration

ABSTRACT: The project investigated chirality-biased proteome during the early stage of bone regeneration on day 3 and day 7.

ORGANISM(S): Rattus Norvegicus

SUBMITTER: Xuliang Deng

PROVIDER: PXD043696 | iProX | Wed Jul 12 00:00:00 BST 2023

REPOSITORIES: iProX

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Chirality-biased protein expression profile during early stages of bone regeneration.

Zeng Qiang Q Zheng Huimin H Heng Boon Chin BC Yao Weitong W Yang Yue Y Jiang Shengjie S Deng Xuliang X

Frontiers in bioengineering and biotechnology 20230718

<b>Introduction:</b> Chirality is a crucial mechanical cue within the extracellular matrix during tissue repair and regeneration. Despite its key roles in cell behavior and regeneration efficacy, our understanding of chirality-biased protein profile in vivo remains unclear. <b>Methods:</b> In this study, we characterized the proteomic profile of proteins extracted from bone defect areas implanted with left-handed and right-handed scaffold matrices during the early healing stage. We identified di ...[more]

PMID: 37533694

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