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Identification of a novel bile marker Clusterin and a public online prediction platform based on deep learning for Cholangiocarcinoma

ABSTRACT: Identification of a novel bile marker Clusterin and a public online prediction platform based on deep learning for Cholangiocarcinoma

ORGANISM(S): Homo Sapiens

SUBMITTER: Wenbo Meng

PROVIDER: PXD043745 | iProX | Thu Jul 13 00:00:00 BST 2023

REPOSITORIES: iProX

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Identification of a novel bile marker clusterin and a public online prediction platform based on deep learning for cholangiocarcinoma.

Gao Long L Lin Yanyan Y Yue Ping P Li Shuyan S Zhang Yong Y Mi Ningning N Bai Mingzhen M Fu Wenkang W Xia Zhili Z Jiang Ningzu N Cao Jie J Yang Man M Ma Yanni Y Zhang Fanxiang F Zhang Chao C Leung Joseph W JW He Shun S Yuan Jinqiu J Meng Wenbo W Li Xun X

BMC medicine 20230808 1

<h4>Background</h4>Cholangiocarcinoma (CCA) is a highly aggressive malignant tumor, and its diagnosis is still a challenge. This study aimed to identify a novel bile marker for CCA diagnosis based on proteomics and establish a diagnostic model with deep learning.<h4>Methods</h4>A total of 644 subjects (236 CCA and 408 non-CCA) from two independent centers were divided into discovery, cross-validation, and external validation sets for the study. Candidate bile markers were identified by three pro ...[more]

PMID: 37553571

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