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Liver samples from WT and Atg7 liver specific KO mice

ABSTRACT: iTRAQ proteomics was performed for Liver samples from WT and Atg7 liver specific KO mice

ORGANISM(S): Mus Musculus

SUBMITTER: Anyuan He

PROVIDER: PXD043936 | iProX | Thu Jul 20 00:00:00 BST 2023

REPOSITORIES: iProX

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Autophagy modulates the stability of Wee1 and cell cycle G2/M transition.

Han Biwei B Chen Yajing Y Song Chen C Chen Yali Y Chen Yong Y Ferguson Daniel D Yang Yunzhi Y He Anyuan A

Biochemical and biophysical research communications 20230804

The mammalian cell cycle is divided into four sequential phases, namely G1 (Gap 1), S (synthesis), G2 (Gap 2), and M (mitosis). Wee1, whose turnover is tightly and finely regulated, is a well-known kinase serving as a gatekeeper for the G2/M transition. However, the mechanism underlying the turnover of Wee1 is not fully understood. Autophagy, a highly conserved cellular process, maintains cellular homeostasis by eliminating intracellular aggregations, damaged organelles, and individual proteins. ...[more]

PMID: 37549603

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