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RNF125 interacting protein detected by IP-Mass

ABSTRACT: After overexpression of RNF125, IP assay was used to detect the RNF125-binding protein and mass spectrometry sequencing was performed

ORGANISM(S): Homo Sapiens

SUBMITTER: Yunxiao Shang

PROVIDER: PXD043937 | iProX | Wed Jul 19 00:00:00 BST 2023

REPOSITORIES: iProX

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Hypermethylation of RNF125 promotes autophagy-induced oxidative stress in asthma by increasing HMGB1 stability.

Hu Jiapeng J Ding Ruiwei R Liu Shaozhuang S Wang Jia J Li Jianjun J Shang Yunxiao Y

iScience 20230727 8

Asthma is a global chronic airway disease. The expression and role of RNF125, an E3 ubiquitin ligase, in asthma remain uncertain. In this study, we revealed that RNF125 was downregulated in the bronchial epithelium of mice and patients with asthma. <i>Rnf125</i> hypermethylation was responsible for the low expression of RNF125 in primary airway epithelial cells of mice treated with OVA. Moreover, we demonstrated that RNF125 could attenuate autophagy, oxidative stress, and protect epithelial barr ...[more]

PMID: 37599832

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