Dataset Information
Extracellular Vesicle Protein Expression Profile of Macrophages
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus Musculus
SUBMITTER: 
Chunyu Bai
PROVIDER: PXD044444 | iProX | Tue Aug 08 00:00:00 BST 2023
REPOSITORIES: iProX
Publications
Transfer of inflammatory mitochondria via extracellular vesicles from M1 macrophages induces ferroptosis of pancreatic beta cells in acute pancreatitis.
Journal of extracellular vesicles 20240201 2
Extracellular vesicles (EVs) exert a significant influence not only on the pathogenesis of diseases but also on their therapeutic interventions, contingent upon the variances observed in their originating cells. Mitochondria can be transported between cells via EVs to promote pathological changes. In this study, we found that EVs derived from M1 macrophages (M1-EVs), which encapsulate inflammatory mitochondria, can penetrate pancreatic beta cells. Inflammatory mitochondria fuse with the mitochon ...[more]
