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Virus-induced lncRNA-BTX allows viral replication by regulating intracellular translocation of DHX9 and ILF3 to induce innate escape

ABSTRACT: Virus-induced lncRNA-BTX allows viral replication by regulating intracellular translocation of DHX9 and ILF3 to induce innate escape

ORGANISM(S): Mus Musculus

SUBMITTER: Yang Cao

PROVIDER: PXD044507 | iProX | Thu Aug 10 00:00:00 BST 2023

REPOSITORIES: iProX

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Virus-induced lncRNA-BTX allows viral replication by regulating intracellular translocation of DHX9 and ILF3 to induce innate escape.

Cao Yang Y Wu Jiacheng J Hu Ye Y Chai Yangyang Y Song Jiaying J Duan Jiaqi J Zhang Song S Xu Xiaoqing X

Cell reports 20231001 10

The roles of long noncoding RNA (lncRNA) and RNA-binding proteins (RBPs) in antiviral innate response warrant further investigation. Here, we identify an lncRNA, termed lncRNA-BTX (between Tbk1 and Xpot), which is upregulated upon viral infection via an IRF3-type I interferon-independent pathway, promoting viral innate immune escape. Deletion of lncRNA-BTX in cells or mice significantly reduces viral load in vitro or in vivo, respectively. Mechanistically, lncRNA-BTX strengthens the interactions ...[more]

PMID: 37864796

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