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The targets study of HDCA in ameliorating NAFLD induced by high-calories diet by multi-omics technology.

ABSTRACT: HDCA supplementation ameliorated diet-induced NAFLD in C57 wild type mice. In attempt to comprehensively understand the molecular mechanism occurring during the protective effect of HDCA, transcriptomic and proteomic profiles of mouse liver were first analyzed utilizing RNA-Sequencing and Tandem Mass Tag-based quantitative proteomic approach, respectively. Then, we screened for potential HDCA binding proteins by using biotin-labeled HDCA and human proteome microarray.

ORGANISM(S): Mus Musculus

SUBMITTER: Houkai Li

PROVIDER: PXD044613 | iProX | Fri Aug 18 00:00:00 BST 2023

REPOSITORIES: iProX

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