Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Heshui Wu
PROVIDER: PXD044671 | iProX | Fri Aug 18 00:00:00 BST 2023
REPOSITORIES: iProX
Sun Yan Y Jin Xin X Meng Junpeng J Guo Feng F Chen Taoyu T Zhao Xiaoyan X Wu Heshui H Ren Dianyun D
The EMBO journal 20231031 23
The Hippo signaling axis is a tumor suppressor pathway that is activated by various extra-pathway factors to regulate cell differentiation and organ development. Recent studies have reported that autophosphorylation of the core kinase cassette stimulates activation of the Hippo signaling cascade. Here, we demonstrate that protein arginine methyltransferase 5 (PRMT5) contributes to inactivation of the Hippo signaling pathway in pancreatic cancer. We show that the Hippo pathway initiator serine/th ...[more]