Proteomic Analysis of Lysine lactylation in adipose tissue of HIIT mice

ABSTRACT: This project carried out a quantitative study of the target proteins that are lactylated and regulated by lactate levels in iWAT of HIIT mice. In order to ensure a high degree of credibility of the results, we quantitatively analyzed the changes in protein lactylation in three groups. Modification sites in both groups with p <0.05 were considered significantly different modifications, and the standard for up- or down-regulated modification sites was set as a fold change >1.3 or <0.7, respectively. In this study, We identified 602 quantifiable sites and 217 quantifiable proteins. Subsequently, we carried out a systematic bioinformatics analysis of proteins containing quantitative information sites, including protein annotation, functional classification, functional enrichment and cluster analysis based on functional enrichment.

ORGANISM(S): Mus <genus>

SUBMITTER: Jing Zhang  

PROVIDER: PXD044919 | iProX | Tue Aug 29 00:00:00 BST 2023

REPOSITORIES: iProX