TAK1 is an essential kinase for STING trafficking
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens Mus Musculus
SUBMITTER: 
Haipeng Liu
PROVIDER: PXD045096 | iProX | Tue Sep 05 00:00:00 BST 2023
REPOSITORIES: iProX
Publications
TAK1 is an essential kinase for STING trafficking.
Ma Mingtong M Dang Yifang Y Chang Boran B Wang Fei F Xu Junfang J Chen Li L Su Hang H Li Jinsong J Ge Baoxue B Chen Chang C Liu Haipeng H
Molecular cell 20231012 21
The translocation of stimulator of interferon genes (STING) from the endoplasmic reticulum (ER) to the ER-Golgi intermediate compartment (ERGIC) enables its activation. However, the mechanism underlying the regulation of STING exit from the ER remains elusive. Here, we found that STING induces the activation of transforming growth factor beta-activated kinase 1 (TAK1) prior to STING trafficking in a TAK1 binding protein 1 (TAB1)-dependent manner. Intriguingly, activated TAK1 directly mediates ST ...[more]
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