Ontology highlight
ABSTRACT:
ORGANISM(S): Cryptococcus Neoformans Var. Grubii H99
SUBMITTER: Yang Meng
PROVIDER: PXD045338 | iProX | Wed Sep 13 00:00:00 BST 2023
REPOSITORIES: iProX
Meng Yang Y Ni Yue Y Li Zhuoran Z Jiang Tianhang T Sun Tianshu T Li Yanjian Y Gao Xindi X Li Hailong H Suo Chenhao C Li Chao C Yang Sheng S Lan Tian T Liao Guojian G Liu Tongbao T Wang Ping P Ding Chen C
eLife 20240122
<i>Cryptococcus neoformans</i> poses a threat to human health, but anticryptococcal therapy is hampered by the emergence of drug resistance, whose underlying mechanisms remain poorly understood. Herein, we discovered that Isw1, an imitation switch chromatin remodeling ATPase, functions as a master modulator of genes responsible for <i>in vivo</i> and <i>in vitro</i> multidrug resistance in <i>C. neoformans</i>. Cells with the disrupted <i>ISW1</i> gene exhibited profound resistance to multiple a ...[more]