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YBX1 promotes homologous recombination and resistance to platinum-induced stress in ovarian cancer by recognizing m5C modification

ABSTRACT: Platinum-based chemotherapy causes genetic damage and induces apoptosis in ovarian cancer cells. Enhancing the ability to resist platinum drug-induced DNA damage and apoptotic stress is critical for tumor cells to acquire drug resistance. Here, we found that Y-box binding protein 1 (YBX1) was highly expressed in platinum-resistant patient-derived organoids (PDOs) and was a crucial gene for alleviating platinum-induced stress and maintaining drug resistance characteristics in ovarian cancer cells.

ORGANISM(S): Homo Sapiens

SUBMITTER: Wenjun Cheng

PROVIDER: PXD045503 | iProX | Tue Sep 19 00:00:00 BST 2023

REPOSITORIES: iProX

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