Study on the treatment of ITP mice with IVIG sourced from distinct sex-special plasma (DSP-IVIG)

ABSTRACT: Intravenous immunoglobulin (IVIG) is a first-line drug prepared from human plasma for the treatment of autoimmune diseases (AID), especially immune thrombocytopenia (ITP). Since significant differences exist in protein types and expression levels between male and female plasma, and the prevalence of autoimmune diseases varies between sexes. The present study seeks to explore potential variations in IVIG sourced from distinct sex-specific plasma (DSP-IVIG), including IVIG sourced from female plasma (F-IVIG), IVIG sourced from male plasma (M-IVIG), and IVIG sourced from a blend of male and female plasma (Mix-IVIG). We investigate whether these IVIG variants exhibit different effects in the treatment of ITP. To address this question, we established an ITP mouse model treated with DSP IVIG.

ORGANISM(S): Mus Musculus

SUBMITTER: Changqing Li  

PROVIDER: PXD045681 | iProX | Tue Sep 26 00:00:00 BST 2023

REPOSITORIES: iProX