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E3 ligase TRIP12 affecting EZH2 ubiquitination in ENKTL

ABSTRACT: Effects of potential E3 ligase that mediates polyubiquitination of EZH2 in extranodal natural killer T cell lymphoma

ORGANISM(S): Homo Sapiens

SUBMITTER: Boheng Li

PROVIDER: PXD046145 | iProX | Sat Oct 14 00:00:00 BST 2023

REPOSITORIES: iProX

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EZH2 K63-polyubiquitination affecting migration in extranodal natural killer/T-cell lymphoma.

Li Boheng B Zhou Qidi Q Wan Qin Q Qiao Xuan X Chen Shangying S Zhou Jianbiao J Wuxiao Zhijun Z Luo Lei L Ng Siok-Bian SB Li Jieping J Chng Wee-Joo WJ

Clinical epigenetics 20231129 1

<h4>Background</h4>Overexpressed EZH2 is oncogenically involved in the pathogenesis of different cancerous contexts including extranodal natural killer/T cell lymphoma (ENKTL). However, the underlying mechanisms of EZH2 upregulation have not been fully clarified and it is still difficult to target EZH2 in ENKTL.<h4>Results</h4>Current study identifies an E3 ligase TRIP12 that triggers K63-linked polyubiquitination of EZH2 in ENKTL and unexpectedly, stabilizes EZH2. As determined by gene expressi ...[more]

PMID: 38031139

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