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HnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain by stabilizing TRPA1 mRNA

ABSTRACT: We show here that the up-regulation of SUMO1-conjugated protein levels in a CFA-induced inflammatory pain model enhances TRPA1 mRNA stability, ultimately leading to increased expression levels. We further demonstrate that hnRNPA1 binds to TRPA1 mRNA and its SUMOylation, up-regulated in CFA-induced inflammatory pain, contributes to stabilizing TRPA1 mRNA by accumulating hnRNPA1 in the cytoplasm.

ORGANISM(S): Cricetulus Griseus

SUBMITTER: Yong Li

PROVIDER: PXD046198 | iProX | Wed Oct 18 00:00:00 BST 2023

REPOSITORIES: iProX

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