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HnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain

ABSTRACT: We show here that the up-regulation of SUMO1-conjugated protein levels in a CFA-induced inflammatory pain model enhances TRPA1 mRNA stability, ultimately leading to increased expression levels.

ORGANISM(S): Homo Sapiens

SUBMITTER: Yong Li

PROVIDER: PXD046199 | iProX | Wed Oct 18 00:00:00 BST 2023

REPOSITORIES: iProX

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hnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain by stabilizing TRPA1 mRNA.

Zhang Qiao Q Weng Weiji W Gu Xiaokun X Xiang Jinhua J Yang Yang Y Zhu Michael X MX Gu Weidong W He Zhenzhou Z Li Yong Y

Cell reports 20231108 11

TRPA1 is pivotal in cold hypersensitivity, but its regulatory mechanisms in inflammatory cold hyperalgesia remain poorly understood. We show here that the upregulation of SUMO1-conjugated protein levels in a complete Freund's adjuvant (CFA)-induced inflammatory pain model enhances TRPA1 mRNA stability, ultimately leading to increased expression levels. We further demonstrate that hnRNPA1 binds to TRPA1 mRNA, and its SUMOylation, upregulated in CFA-induced inflammatory pain, contributes to stabil ...[more]

PMID: 37943660

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