Ontology highlight
ABSTRACT:
ORGANISM(S): Homo Sapiens
SUBMITTER: Yong Li
PROVIDER: PXD046199 | iProX | Wed Oct 18 00:00:00 BST 2023
REPOSITORIES: iProX
Zhang Qiao Q Weng Weiji W Gu Xiaokun X Xiang Jinhua J Yang Yang Y Zhu Michael X MX Gu Weidong W He Zhenzhou Z Li Yong Y
Cell reports 20231108 11
TRPA1 is pivotal in cold hypersensitivity, but its regulatory mechanisms in inflammatory cold hyperalgesia remain poorly understood. We show here that the upregulation of SUMO1-conjugated protein levels in a complete Freund's adjuvant (CFA)-induced inflammatory pain model enhances TRPA1 mRNA stability, ultimately leading to increased expression levels. We further demonstrate that hnRNPA1 binds to TRPA1 mRNA, and its SUMOylation, upregulated in CFA-induced inflammatory pain, contributes to stabil ...[more]